FKBP12 PROTAC dTAG-13

• CAT Number: I017647
• CAS Number: 2064175-41-1
• Molecular Formula: C₅₇H₆₈N₄O₁₅
• Molecular Weight: 1049.17
• Purity: ≥95%
• Target: Immunology/Inflammation
• IUPAC Name: [(1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[6-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyhexylamino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
• InChI: InChI=1S/C57H68N4O15/c1-7-37(36-32-47(71-4)52(73-6)48(33-36)72-5)54(65)60-29-14-12-19-41(60)57(68)76-43(25-22-35-23-26-44(69-2)46(31-35)70-3)38-17-10-11-20-42(38)75-34-50(63)58-28-13-8-9-15-30-74-45-21-16-18-39-51(45)56(67)61(55(39)66)40-24-27-49(62)59-53(40)64/h10-11,16-18,20-21,23,26,31-33,37,40-41,43H,7-9,12-15,19,22,24-25,27-30,34H2,1-6H3,(H,58,63)(H,59,62,64)/t37-,40?,41-,43+/m0/s1
• InChIKey: BJFBRLAWLPZOMJ-QHVFGHLPSA-N
• SMILES: CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC=CC=C4OCC(=O)NCCCCCCOC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O

FKBP12 PROTAC dTAG-13(CAT: I017647) is a small-molecule heterobifunctional degrader designed to target FKBP12 for proteasomal degradation. It functions by harnessing the ubiquitin-proteasome system through the formation of a ternary complex between FKBP12, a ligand for the E3 ubiquitin ligase, and the proteasome. This targeted protein degradation approach enables precise modulation of FKBP12 levels, offering a powerful tool for studying its role in cellular processes. FKBP12 PROTAC dTAG-13 is widely used in research on protein degradation technologies, signal transduction, and the development of therapeutic strategies leveraging PROTAC technology.