For research use only. Not for therapeutic Use.
FL104 (Cat No.: I006801) is a small-molecule anticancer agent designed to inhibit survivin, a member of the inhibitor of apoptosis (IAP) protein family that is overexpressed in many tumors. By suppressing survivin expression, FL104 promotes cancer cell apoptosis and disrupts mitotic progression, making it effective against various cancer types. It has shown potent antitumor activity in preclinical models, including in drug-resistant and metastatic cancers. FL104 is primarily used in oncology research to explore survivin-targeted therapies and improve treatment strategies for aggressive, treatment-resistant tumors.
| CAS Number | 885672-81-1 |
| Synonyms | FL104; FL 104; FL-104.;N-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-4-phenylbenzamide |
| Molecular Formula | C24H25ClN2O |
| Purity | ≥95% |
| Target | Urotensin II Receptor Agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | N-[1-(4-chlorophenyl)-3-(dimethylamino)propyl]-4-phenylbenzamide |
| InChI | InChI=1S/C24H25ClN2O/c1-27(2)17-16-23(20-12-14-22(25)15-13-20)26-24(28)21-10-8-19(9-11-21)18-6-4-3-5-7-18/h3-15,23H,16-17H2,1-2H3,(H,26,28) |
| InChIKey | JXJCJZNVWYQHIF-UHFFFAOYSA-N |
| SMILES | CN(C)CCC(C1=CC=C(C=C1)Cl)NC(=O)C2=CC=C(C=C2)C3=CC=CC=C3 |
| Reference | </br>1:Lehmann F, Currier EA, Clemons B, Hansen LK, Olsson R, Hacksell U, Luthman K. Novel and potent small-molecule urotensin II receptor agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4657-65. doi: 10.1016/j.bmc.2009.04.062. PubMed PMID: 19481466.</br>2: Lehmann F, Lake L, Currier EA, Olsson R, Hacksell U, Luthman K. Design, parallel synthesis and SAR of novel urotensin II receptor agonists. Eur J Med Chem. 2007 Feb;42(2):276-85. PubMed PMID: 17112638. |
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