FL118-C3-O-C-amide-C-NH2 formate

• CAT Number: I040103
• Molecular Formula: C28H30N4O10
• Molecular Weight: 582.56
• Purity: ≥95%
• Synonyms: 2-amino-N-[3-[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]propoxymethyl]acetamide;formic acid
• InChI: InChI=1S/C27H28N4O8.CH2O2/c1-2-27(35)18-7-20-24-16(10-31(20)25(33)17(18)11-37-26(27)34)14(4-3-5-36-12-29-23(32)9-28)15-6-21-22(39-13-38-21)8-19(15)30-24;2-1-3/h6-8,35H,2-5,9-13,28H2,1H3,(H,29,32);1H,(H,2,3)/t27-;/m0./s1
• InChIKey: LZHPLMWCKDQPNH-YCBFMBTMSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCO6)CCCOCNC(=O)CN)O.C(=O)O

FL118-C3-O-C-amide-C-NH2 formate (Cat No.: I040103) is a modified derivative of FL118, a potent anticancer agent. This compound features a C3-O linkage and an amide group, which may enhance its stability, solubility, and bioavailability. The formate salt form helps improve the compound’s pharmacokinetic properties, making it more suitable for preclinical and clinical applications. FL118 itself has shown promising activity against various cancers, including colon, lung, and liver cancer, by inhibiting critical pathways involved in tumor growth, survival, and metastasis.

Reference

[1]. Song Shuai, et al. Preparation method for drug linker conjugate. WO2023143208A1.