For research use only. Not for therapeutic Use.
Flavoxate is an anticholinergic with antimuscarinic effects. Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem.
| Catalog Number | M075476 |
| CAS Number | 15301-69-6 |
| Molecular Formula | C24H25NO4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate |
| InChI | InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3 |
| InChIKey | SPIUTQOUKAMGCX-UHFFFAOYSA-N |
| SMILES | CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4 |
| Reference | </br>1:Flavoxate in the symptomatic treatment of overactive bladder: a meta-analysis. Sweeney P, Mutambirwa S, Van An N, Sharma JB, Vanamail P.Eur Rev Med Pharmacol Sci. 2016 Sep;20(17):3703-12. PMID: 27649675 Free Article</br>2:[Fluorescence enhancement of flavoxate hydrochloride in alkali solution and its application in pharmaceutical analysis]. Li WH, Sun CM, Wei YJ.Yao Xue Xue Bao. 2015 Oct;50(10):1324-9. Chinese. PMID: 26837181 </br>3:Short-Term Flavoxate Treatment Alters Detrusor Contractility Characteristics: Renewed Interest in Clinical Use? Tang HC, Lam WP, Zhang X, Leung PC, Yew DT, Liang W.Low Urin Tract Symptoms. 2015 Sep;7(3):149-54. doi: 10.1111/luts.12063. Epub 2014 Jun 3. PMID: 26663730 </br>4:Flavoxate: present and future. Arcaniolo D, Conquy S, Tarcan T.Eur Rev Med Pharmacol Sci. 2015;19(5):719-31. Review. PMID: 25807422 Free Article</br>5:Flavoxate in urogynecology: an old drug revisited. Zor M, Aydur E, Dmochowski RR.Int Urogynecol J. 2015 Jul;26(7):959-66. doi: 10.1007/s00192-014-2585-5. Epub 2014 Dec 6. Review. PMID: 25480503 </br>6:Spectrofluorimetric determination of 3-methylflavone-8-carboxylic acid, the main active metabolite of flavoxate hydrochloride in human urine. Zaazaa HE, Mohamed AO, Hawwam MA, Abdelkawy M.Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 5;134:109-13. doi: 10.1016/j.saa.2014.06.058. Epub 2014 Jun 20. PMID: 25004902 </br>7:Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. Sugaya K, Nishijima S, Kadekawa K, Ashitomi K, Ueda T, Yamamoto H.J Urol. 2014 Oct;192(4):1278-85. doi: 10.1016/j.juro.2014.04.092. Epub 2014 Apr 30. PMID: 24793729 </br>8:Erythema and hand edema due to flavoxate. Moreno Escobosa MC, Cruz Granados S, Moya Quesada MC.J Investig Allergol Clin Immunol. 2012;22(5):390-1. No abstract available. PMID: 23101324 Free Article</br>9:Simultaneous Determination of Ofloxacin and Flavoxate Hydrochloride by Absorption Ratio and Second Derivative UV Spectrophotometry. Attimarad M.J Basic Clin Pharm. 2010 Dec;2(1):53-61. Epub 2011 Feb 15. PMID: 24826003 Free PMC Article</br>10:Liquid Chromatographic Determination of Flavoxate HCl in Pharmaceutical Formulation. Attimarad M.J Young Pharm. 2010 Jul;2(3):280-3. doi: 10.4103/0975-1483.66787. PMID: 21042486 Free PMC Article |
