Floxuridine

• CAT Number: A000292
• CAS Number: 50-91-9
• Molecular Formula: C9H11FN2O5
• Molecular Weight: 246.20
• Purity: ≥95%
• Synonyms: 50-91-9; 5-Fluoro-2/’-deoxyuridine; 2/’-Deoxy-5-fluorouridine; 5-Fluorodeoxyuridine; FUDR
• Target: Anti-infection
• Solubility: >12.3mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• InChI: InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
• InChIKey: ODKNJVUHOIMIIZ-RRKCRQDMSA-N
• SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O

Floxuridine（Cat No.:A000292）is an antimetabolite used primarily in the treatment of certain cancers, especially metastatic colorectal cancer. It functions as a nucleoside analog, interfering with DNA synthesis and cell division by inhibiting thymidylate synthase, which is crucial for DNA replication. Administered intravenously, floxuridine is often used in combination with other chemotherapy agents to enhance efficacy. Side effects may include myelosuppression, gastrointestinal disturbances, and mucositis. Due to its specific action on rapidly dividing cells, floxuridine is effective against tumors but requires careful monitoring for toxicity.

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