FLT3-IN-2

• CAT Number: I005494
• CAS Number: 923562-23-6
• Molecular Formula: C21H16ClF3N4
• Molecular Weight: 416.83
• Purity: ≥95%
• Target: FLT3
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IC50: IC50 of ＜ 1 μM
• IUPAC Name: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyridin-2-amine
• InChI: InChI=1S/C21H16ClF3N4/c22-17-8-18-15(11-28-20(18)29-12-17)7-14-3-6-19(27-10-14)26-9-13-1-4-16(5-2-13)21(23,24)25/h1-6,8,10-12H,7,9H2,(H,26,27)(H,28,29)
• InChIKey: MFXPJGJSKHZZGC-UHFFFAOYSA-N
• SMILES: FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=C1)(F)F

FLT3-IN-2(CAT: I005494) is a potent and selective inhibitor of FMS-like tyrosine kinase 3 (FLT3), a key receptor tyrosine kinase involved in hematopoiesis and leukemogenesis. It effectively targets wild-type FLT3 and FLT3 mutations, such as FLT3-ITD, which are commonly associated with acute myeloid leukemia (AML). By inhibiting FLT3 signaling, FLT3-IN-2 disrupts pathways that drive cell proliferation and survival in FLT3-dependent cancers. Its high potency and selectivity make it a valuable tool for in vitro and in vivo studies focused on AML and other hematologic malignancies. FLT3-IN-2 supports the development of targeted therapies and advances research in cancer biology.