Fluciclovine (18F)

• CAT Number: I048042
• CAS Number: 222727-39-1
• Molecular Formula: C5H8FNO2
• Molecular Weight: 132.1
• Purity: ≥95%
• Synonyms: Fluciclovine F-18; axumin
• Target: SLC1A5
• Target Protein: NTEDWGYJNHZKQW-KWCOIAHCSA-N
• Appearance: Solid
• IUPAC Name: 1-amino-3-(18F)fluoranylcyclobutane-1-carboxylic acid
• InChI: InChI=1S/C5H8FNO2/c6-3-1-5(7,2-3)4(8)9/h3H,1-2,7H2,(H,8,9)/i6-1
• SMILES: C1C(CC1(C(=O)O)N)F

Fluciclovine (18F), also known as Axumin, is a radiopharmaceutical used in positron emission tomography (PET) imaging to detect recurrent prostate cancer. It is a synthetic amino acid analog labeled with the radioactive isotope fluorine-18. Fluciclovine is preferentially taken up by prostate cancer cells due to their increased amino acid transport. PET imaging with Fluciclovine (18F) can detect and localize areas of increased amino acid metabolism, which may indicate the presence of recurrent prostate cancer. This imaging technique aids in the staging and management of prostate cancer, especially in cases of biochemical recurrence following initial treatment.