FLUCYBENE(cas 3289-22-3) is a potent non-competitive GABA antagonist in mammalian, molluscan and insects, a convulsant and a laboratory insecticide.
Organofluorate compound, synthetic
(IC50) for blocking the GABA-dependent [<sup>36</sup>Cl] uptake in rat brain synaptosomes: 50 nM; <br>Inhibition of the GABA-dependent Cl- current at 61.0 nM;<br>Experiments with [<sup>3</sup>H]-labelled GABA-competitive ligands (muscimol, GABA) showed no influence of Flucybene up to 10 μM.
| Catalog Number | T000116 |
| CAS Number | 3289-22-3 |
| Molecular Formula | C11H6F6N2 |
| Purity | ≥95% |
| Solubility | In alcohol, alcohol + water and acetone. |
| Storage | Store at room temperature. 1 mg Cloflubicyne can be dissolved in 1 ml ethanol (up to 50 °C), then diluted in distilled water. Solution for experiments must contain less than 0.5 % ethanol and be stored at 0 °C. |
| Reference | – Middelton et al., <i>J. Fluor. Chem.</i>(1982) 20:397-418<br /> |
