Fludarabine triphosphate

• CAT Number: I010762
• CAS Number: 74832-57-8
• Molecular Formula: C₁₀H₁₅FN₅O₁₃P₃
• Molecular Weight: 525.17
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• IUPAC Name: [[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• InChI: InChI=1S/C10H15FN5O13P3/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1
• InChIKey: PIOKUWLZUXUBCO-FJFJXFQQSA-N
• SMILES: C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)F)N

Fludarabine triphosphate（Cat No.:I010762）is the active metabolite of fludarabine, a purine nucleoside analog used primarily in the treatment of hematological malignancies, such as chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma. It inhibits DNA polymerase, ribonucleotide reductase, and DNA primase, disrupting DNA synthesis and repair in rapidly dividing cancer cells. Fludarabine triphosphate is incorporated into DNA, leading to chain termination and apoptosis. Its high efficacy in targeting cancer cells with minimal effects on non-dividing cells makes it a critical agent in chemotherapy regimens for blood cancers.