Fludarabine triphosphate trisodium

• CAT Number: I042844
• CAS Number: 74832-57-8
• Molecular Formula: C10H12FN5Na3O13P3
• Molecular Weight: 591.12
• Purity: ≥95%
• Synonyms: trisodium;[[[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate
• InChI: InChI=1S/C10H15FN5O13P3.3Na/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21);;;/q;3*+1/p-3/t3-,5-,6+,9-;;;/m1.../s1
• InChIKey: ABCNYMXTKKBAHQ-ABDPYLPCSA-K
• SMILES: C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O)O)F)N.[Na+].[Na+].[Na+]

Fludarabine triphosphate trisodium（Cat No.:I042844）is the active metabolite of fludarabine, a chemotherapy drug used in the treatment of certain types of leukemia, such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. As a purine nucleoside analog, fludarabine triphosphate interferes with DNA synthesis and repair by inhibiting DNA polymerase and causing strand breaks, leading to cell death. It is highly effective in targeting rapidly dividing cancer cells. Fludarabine triphosphate trisodium is utilized in both intravenous and oral formulations for treating hematologic malignancies, with ongoing studies to optimize its clinical use.