Flufenamic acid

• CAT Number: A000160
• CAS Number: 530-78-9
• Molecular Formula: C14H10F3NO2
• Molecular Weight: 281.2
• Purity: ≥95%
• Synonyms: 530-78-9; Fluphenamic acid; Nichisedan; Achless; Arlef
• Target: COX Inhibitor
• Storage: -20°C
• InChI: 1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
• InChIKey: LPEPZBJOKDYZAD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F

Flufenamic Acid (also known as CI-440, CN-27554, and INF-1837) is a cyclooxygenase inhibitor used to treat inflammation and pain.

Flufenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs:718 Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. Flufenamic acid is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.

It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects. It is generally not available in the US. It is available in some Asian and European countries as a generic.

Scientists led by Claude Winder from Parke-Davis invented flufenamic acid in 1963, along with fellow members of the class, mefenamic acid in 1961 and meclofenamate sodium in 1964.

Reference

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