For research use only. Not for therapeutic Use.
Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 – 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges. A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates. (Source: http://pharmplex.com.au/Technical/fluorogestone_acetate_sheep_goat.htm).
| Catalog Number | R049498 |
| CAS Number | 2529-45-5 |
| Synonyms | (11β)-17-(Acetyloxy)-9-fluoro-11-hydroxy-pregn-4-ene-3,20-dione; 17α-Acetoxy-9α-fluoro-11β-hydroxy-pregn-4-ene-3,20-dione; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone; Gyncro-Mate; NSC 65411; |
| Molecular Formula | C23H31FO5 |
| Purity | ≥95% |
| Target | GnRH Receptor |
| Storage | -20°C |
| IUPAC Name | [(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |
| InChI | InChI=1S/C23H31FO5/c1-13(25)22(29-14(2)26)10-8-17-18-6-5-15-11-16(27)7-9-20(15,3)23(18,24)19(28)12-21(17,22)4/h11,17-19,28H,5-10,12H2,1-4H3/t17-,18-,19-,20-,21-,22-,23-/m0/s1 |
| InChIKey | JKQQZJHNUVDHKP-FQJIPJFPSA-N |
| SMILES | CC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)OC(=O)C |
| Reference | </br>1: Quintero-Elisea JA, MacÃas-Cruz U, Ã</br> |
