Flumethasone

• CAT Number: A000824
• CAS Number: 2135-17-3
• Molecular Formula: C22H28F2O5
• Molecular Weight: 410.45
• Purity: ≥95%
• Synonyms: Flumetasone; 2135-17-3; Aniprime; Flucorticin; Flumethason
• Target: Fungal
• Storage: -20°C
• InChI: 1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
• InChIKey: WXURHACBFYSXBI-GQKYHHCASA-N
• SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F

Flumetasone, also known as RS 2177, is a corticosteroid for topical use. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.

Reference

1: Zhang D, Park JA, Kim SK, Cho SH, Jeong D, Cho SM, Yi H, Shim JH, Kim JS, Abd
El-Aty AM, Shin HC. Simultaneous detection of flumethasone, dl-methylephedrine,
and 2-hydroxy-4,6-dimethylpyrimidine in porcine muscle and pasteurized cow milk
using liquid chromatography coupled with triple-quadrupole mass spectrometry. J
Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:8-16. doi:
10.1016/j.jchromb.2016.01.011. Epub 2016 Jan 12. PubMed PMID: 26797492.

2: Abdel-Aleem EA, Hegazy MA, Sayed NW, Abdelkawy M, Abdelfatah RM. Novel
spectrophotometric determination of flumethasone pivalate and clioquinol in their
binary mixture and pharmaceutical formulation. Spectrochim Acta A Mol Biomol
Spectrosc. 2015 Feb 5;136 Pt B:707-13. doi: 10.1016/j.saa.2014.09.085. Epub 2014
Sep 30. PubMed PMID: 25448970.

3: Park KH, Choi JH, Abd El-Aty AM, Cho SK, Park JH, Kwon KS, Park HR, Kim HS,
Shin HC, Kim MR, Shim JH. Development of QuEChERS-based extraction and liquid
chromatography-tandem mass spectrometry method for quantifying flumethasone
residues in beef muscle. Meat Sci. 2012 Dec;92(4):749-53. doi:
10.1016/j.meatsci.2012.06.033. Epub 2012 Jun 29. PubMed PMID: 22819726.

4: List RJ, Flook EP, Tay HL. Tympanoplasty graft preparation using ear drops
containing polyethylene glycol, flumethasone and clioquinol. J Laryngol Otol.
2011 Aug;125(8):853-5. doi: 10.1017/S0022215111001083. Epub 2011 May 31. PubMed
PMID: 21729449.

5: Van Den Hauwe O, Schneider M, Sahin A, Van Peteghem CH, Naegeli H.
Immunochemical screening and liquid chromatographic-tandem mass spectrometric
confirmation of drug residues in edible tissues of calves injected with a
therapeutic dose of the synthetic glucocorticoids dexamethasone and flumethasone.
J Agric Food Chem. 2003 Jan 1;51(1):326-30. PubMed PMID: 12502428.

6: Brambilla G, Buiarelli F, Cartoni GP, Coccioli F, Colamonici C, Fagiolo A,
Giannini C, Neri B. Determination of flumethasone in calf urine and serum by
liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl.
2001 May 5;755(1-2):265-78. PubMed PMID: 11393713.

7: Sternbauer K, Luthman J, Jacobsson SO. Flumethasone-induced insulin resistance
in calves. Zentralbl Veterinarmed A. 1998 Sep;45(6-7):441-3. PubMed PMID:
9793474.

8: Reding J, Sahin A, Schlatter J, Naegeli H. Dexamethasone and flumethasone
residues in milk of intramuscularly dosed cows. J Vet Pharmacol Ther. 1997
Jun;20(3):198-203. PubMed PMID: 9185085.

9: Sustronck B, Deprez P, van Loon G, Coghe J, Muylle E. Efficacy of the
combination sodium ceftiofur-flumethasone in the treatment of experimental
Pasteurella haemolytica bronchopneumonia in calves. Zentralbl Veterinarmed A.
1997 May;44(3):179-87. PubMed PMID: 9197206.

10: Gu X, Meleka-Boules M, Chen CL. Micellar electrokinetic capillary
chromatography combined with immunoaffinity chromatography for identification and
determination of dexamethasone and flumethasone in equine urine. J Capillary
Electrophor. 1996 Jan-Feb;3(1):43-9. PubMed PMID: 9384764.