Flumizole

• CAT Number: I006813
• CAS Number: 36740-73-5
• Molecular Formula: C18H15F3N2O2
• Molecular Weight: 348.32
• Purity: ≥95%
• Synonyms: Flumizole; UNII-Y4YQF944N9; CP-22665; Flumizolum; Flumizol; Flumizole (USAN/INN); AC1L1XWB; Flumizol [INN-Spanish]; CP 22665. CP-22,665.;4,5-Bis(p-methoxyphenyl)-2-(trifluoromethyl)imidazole
• Solubility: Soluble in DMSO, not in water
• Storage: -20°C
• IUPAC Name: 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole
• InChI: InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)
• InChIKey: OPYFPDBMMYUPME-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=C(N=C(N2)C(F)(F)F)C3=CC=C(C=C3)OC

Flumizole(CAT: I006813) is a selective inhibitor of aryl hydrocarbon receptor (AhR) signaling, a pathway involved in xenobiotic metabolism, immune regulation, and cancer progression. By antagonizing AhR activation, Flumizole modulates gene expression related to detoxification enzymes, such as cytochrome P450, and influences immune responses. This compound is a valuable tool in immunology and toxicology research, particularly for studying AhR’s role in inflammatory diseases, autoimmune disorders, and tumorigenesis. Flumizole provides insights into AhR-targeted therapies, offering potential strategies for managing conditions associated with dysregulated AhR activity, such as chronic inflammation and environmental toxin exposure.