For research use only. Not for therapeutic Use.
Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.
IC50 value:
Target: Fungicide agent
Flumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore germination and hyphal growth. In flumorph-treated hyphae, the most characteristic change was the development of periodic swelling (“beaded” morphology) and the disruption of tip growth. Upon removing flumorph, normal tip growth and organized F-actin were observed again [1]. Flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen [2].
| Catalog Number | I002629 |
| CAS Number | 211867-47-9 |
| Synonyms | (E)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholin-4-ylprop-2-en-1-one |
| Molecular Formula | C21H22FNO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H22FNO4/c1-25-19-8-5-16(13-20(19)26-2)18(15-3-6-17(22)7-4-15)14-21(24)23-9-11-27-12-10-23/h3-8,13-14H,9-12H2,1-2H3/b18-14+ |
| InChIKey | BKBSMMUEEAWFRX-NBVRZTHBSA-N |
| SMILES | COC1=C(C=C(C=C1)C(=CC(=O)N2CCOCC2)C3=CC=C(C=C3)F)OC |
| Reference | [1]. Sheng Zhu S, et al. Flumorph Is a Novel Fungicide That Disrupts Microfilament Organization in Phytophthora melonis. Phytopathology. 2007 May;97(5):643-9. [2]. Zhang T, et al. Assessment of genotoxic effects of flumorph by the comet assay in mice organs. Hum Exp Toxicol. 2014 Mar;33(3):224-9. |
