Flunarizine-d8 Dihydrochloride

• CAT Number: R042341
• CAS Number: 1415586-83-2
• Molecular Formula: C26H26F2N2
• Molecular Weight: 412.554
• Purity: ≥95%
• Synonyms: 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine-d8 Hydrochloride; Dinaplex-d8; Flugeral-d8; Flunagen-d8; Flunarl-d8; Fluxarten-d8; Gradient-d8; Issium-d8; Mondus-d8; R 14950-d8
• Storage: -20°C
• Related CAS: 30484-77-6 (unlabeled)
• IUPAC Name: 1-[bis(4-fluorophenyl)methyl]-2,2,3,3,5,5,6,6-octadeuterio-4-[(E)-3-phenylprop-2-enyl]piperazine
• InChI: InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+/i17D2,18D2,19D2,20D2
• InChIKey: SMANXXCATUTDDT-XSAGKOFCSA-N
• SMILES: [2H]C1(C(N(C(C(N1C/C=C/C2=CC=CC=C2)([2H])[2H])([2H])[2H])C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)([2H])[2H])[2H]

Flunarizine-d8 Dihydrochloride is a deuterated form of flunarizine, a calcium channel blocker used to prevent migraines and treat vertigo. The incorporation of eight deuterium atoms allows for enhanced tracking and analysis in pharmacokinetic and metabolic studies through NMR spectroscopy and mass spectrometry. This isotopically labeled compound helps researchers understand the drug’s absorption, distribution, metabolism, and excretion (ADME) processes. Flunarizine-d8 Dihydrochloride is crucial in optimizing dosing regimens, investigating drug interactions, and improving the overall safety and efficacy of flunarizine in clinical applications.