For research use only. Not for therapeutic Use.
Flunarizine (Cat.No:I006814) is a non-selective calcium entry blocker with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (both of these conditions share a mutation in the ATP13A gene). Flunarizine has also been shown to significantly reduce headache frequency and severity in both adults and children.
| Catalog Number | I006814 |
| CAS Number | 52468-60-7 |
| Synonyms | Flunarizine, Sibelium, Flunarizina, Flunarizinum, Flunarizin, R-14950;1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine |
| Molecular Formula | C26H26F2N2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| IUPAC Name | 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine |
| InChI | InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+ |
| InChIKey | SMANXXCATUTDDT-QPJJXVBHSA-N |
| SMILES | C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F |
| Reference | </br>1:Extrapyramidal symptoms after exposure to calcium channel blocker-flunarizine or cinnarizine. Jhang KM, Huang JY, Nfor ON, Tung YC, Ku WY, Lee CT, Liaw YP.Eur J Clin Pharmacol. 2017 Apr 6. doi: 10.1007/s00228-017-2247-x. [Epub ahead of print] PMID: 28386684 </br>2:Flunarizine suppresses endothelial Angiopoietin-2 in a calcium – dependent fashion in sepsis. Retzlaff J, Thamm K, Ghosh CC, Ziegler W, Haller H, Parikh SM, David S.Sci Rep. 2017 Mar 9;7:44113. doi: 10.1038/srep44113. PMID: 28276491 Free PMC Article</br>3:Fabrication, Characterization, In-vitro Evaluation of Solid Lipid Nanoemulsion of Flunarizine dihydrochloride for Nasal Delivery. Kaur H, Newton MJ.Antiinflamm Antiallergy Agents Med Chem. 2016 Dec 16. [Epub ahead of print] PMID: 27993106 </br>4:Risk of parkinsonism induced by flunarizine or cinnarizine: a population-based study. Lin HL, Lin HC, Tseng YF, Chen SC, Hsu CY.Eur J Clin Pharmacol. 2017 Mar;73(3):365-371. doi: 10.1007/s00228-016-2181-3. Epub 2016 Dec 16. PMID: 27986997 </br>5:Flunarizine rescues reduced lifespan in CLN3 triple knock-out Caenorhabditis elegans model of batten disease. Kwon YJ, Falk MJ, Bennett MJ.J Inherit Metab Dis. 2017 Mar;40(2):291-296. doi: 10.1007/s10545-016-9986-1. Epub 2016 Oct 20. PMID: 27766444 </br>6:Zhengtian Capsule versus flunarizine in patients with migraine: a multi-center, double-blind, double-dummy, randomized controlled, non-inferior clinical trial. Cao K, Han F, Lin A, Yang W, Zhao J, Zhang H, Ding Y, Xie W, Xu Y, Yu T, Wang X, Yang X, Zhou J, Hou Q, Yu L, Gao Y.BMC Complement Altern Med. 2016 Sep 13;16:356. doi: 10.1186/s12906-016-1321-8. PMID: 27618916 Free PMC Article</br>7:Flunarizine versus topiramate for chronic migraine prophylaxis: a randomized trial. Lai KL, Niddam DM, Fuh JL, Chen SP, Wang YF, Chen WT, Wu JC, Wang SJ.Acta Neurol Scand. 2017 Apr;135(4):476-483. doi: 10.1111/ane.12626. Epub 2016 Jun 16. PMID: 27306581 </br>8:INVESTIGATION AND OPTIMIZATION OF TITRIMETRIC AND SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF FLUNARIZINE DIHYDROCHLORIDE USING IN SITU BROMINE. Prashanth KN, Swamy N, Basavaiah K.Acta Pol Pharm. 2016 Jan-Feb;73(1):35-45. PMID: 27008799 </br>9:Flunarizine arrests hepatitis C virus membrane fusion. Prigozhin DM, Modis Y.Hepatology. 2016 Jan;63(1):14-6. doi: 10.1002/hep.28224. Epub 2015 Oct 30. No abstract available. PMID: 26389725 Free PMC Article</br>10:Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1. Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T.Hepatology. 2016 Jan;63(1):49-62. doi: 10.1002/hep.28111. Epub 2015 Oct 9. PMID: 26248546 Free PMC Article |
