Fluorescent probe QG-1

• CAT Number: I047625
• CAS Number: 2098563-70-1
• Molecular Formula: C19H21N3O3
• Molecular Weight: 339.39
• Purity: ≥95%
• IUPAC Name: (E)-2-cyano-3-[7-(diethylamino)-2-oxochromen-3-yl]-N,N-dimethylprop-2-enamide
• InChI: InChI=1S/C19H21N3O3/c1-5-22(6-2)16-8-7-13-9-14(19(24)25-17(13)11-16)10-15(12-20)18(23)21(3)4/h7-11H,5-6H2,1-4H3/b15-10+
• SMILES: CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)/C=C(\C#N)/C(=O)N(C)C

Fluorescent probe QG-1 is a reversible fluorescence probe, which is suitable for use in the real-time monitoring and quantification of GSH under physiological conditions (Kd value of 2.59 mM). Moreover, QG-1 exhibits a fast response time (t1/2 = 5.82 sec), displays extremely low cytotoxicity and can be employed to determine the actual GSH variations in HeLa cells.
KEYWORDS: Fluorescent probe QG-1 | supplier | Labeling agent | QG1 | QG 1 | QG-1 | CAS [2098563-70-1] | Non Selective (Glutathione) | Glutathione | Fluorescent | Biomarkers & Labeling reagents | GSH

Reference

Z Liu et al. A Reversible Fluorescent Probe for Real-Time Quantitative Monitoring of Cellular Glutathione. Angew Chem Int Ed Engl. 2017 May 15;56(21):5812-5816.