For research use only. Not for therapeutic Use.
Fluorobexarotene (Cat.No:I010887) is a derivative of bexarotene, a retinoid receptor agonist used in the treatment of cutaneous T-cell lymphoma. Fluorobexarotene incorporates a fluorine atom, enhancing its pharmacokinetic properties. It exhibits potent antiproliferative and differentiation-inducing effects on cancer cells, potentially offering improved therapeutic benefits compared to bexarotene. Clinical studies are ongoing to assess its efficacy and safety.
| Catalog Number | I010887 |
| CAS Number | 1190848-23-7 |
| Synonyms | 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid |
| Molecular Formula | C24H27FO2 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Storage | Store at 4℃ |
| IUPAC Name | 2-fluoro-4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid |
| InChI | InChI=1S/C24H27FO2/c1-14-11-19-20(24(5,6)10-9-23(19,3)4)13-18(14)15(2)16-7-8-17(22(26)27)21(25)12-16/h7-8,11-13H,2,9-10H2,1,3-6H3,(H,26,27) |
| InChIKey | LWKAWHRSPCHMPJ-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1C(=C)C3=CC(=C(C=C3)C(=O)O)F)C(CCC2(C)C)(C)C |
