Fluoroestradiol F-18

• CAT Number: I048032
• CAS Number: 94153-53-4
• Molecular Formula: C18H23FO2
• Molecular Weight: 289.4
• Purity: ≥95%
• Synonyms: Fluoroestradiol F18; F-18 Fes; Fes F-18; cerianna
• Target: ESR1 ESR2
• Target Protein: KDLLNMRYZGUVMA-ZYMZXAKXSA-N
• Appearance: Solid
• IUPAC Name: (8R,9S,13S,14S,16R,17R)-16-(18F)fluoranyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• InChI: InChI=1S/C18H23FO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h3,5,8,13-17,20-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i19-1
• SMILES: CC12CCC3C(C1CC(C2O)F)CCC4=C3C=CC(=C4)O

Fluoroestradiol F-18 (FES) is a radioactive tracer used in positron emission tomography (PET) imaging to detect estrogen receptor-positive (ER+) tumors, particularly in breast cancer. FES is a synthetic form of the hormone estradiol, which has a high affinity for estrogen receptors. By labeling FES with the radioactive isotope fluorine-18, it becomes detectable using PET scans, allowing for the visualization of ER+ tumors in the body. This imaging technique helps in diagnosing, staging, and monitoring breast cancer, as well as assessing the effectiveness of hormone therapies targeting estrogen receptors.