For research use only. Not for therapeutic Use.
Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
| Catalog Number | R051841 |
| CAS Number | 426-13-1 |
| Synonyms | (6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; 21-Desoxy-9α-fluoro-6-methylprednisolone; 6α-Methyl-9α-fluoro-?11β,17α-dihydroxypregna-1,4-diene-3,20-dione; 6α-Methyl-9α-fluoro-21-?desoxyprednisolone; 9α-Fluoro-11β,17α-dihydrox |
| Molecular Formula | C22H29FO4 |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Storage | Store at +4C |
| IUPAC Name | (6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| InChI | InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 |
| InChIKey | FAOZLTXFLGPHNG-KNAQIMQKSA-N |
| SMILES | CC1CC2C3CCC(C3(CC(C2(C4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O |
| Reference | </br>1:Comparison of Loteprednol with Fluorometholone after Myopic Photorefractive Keratectomy. Karimian F, Faramarzi A, Fekri S, Mohammad-Rabie H, Najdi D, Doozandeh A, Delfaza-Baher S, Yaseri M.J Ophthalmic Vis Res. 2017 Jan-Mar;12(1):11-16. doi: 10.4103/2008-322X.200161. PMID: 28299001 Free PMC Article</br>2:Dose Uniformity of Topical Corticosteroids: A Simulated Trial of Fluorometholone Acetate 0.1% and Loteprednol Etabonate Gel 0.5. Stevens CE, Bennion JL, Caldwell MC, Townley JR, Apsey DA, Schwertner HA.J Ocul Pharmacol Ther. 2017 Mar;33(2):111-114. doi: 10.1089/jop.2016.0151. Epub 2017 Jan 31. PMID: 28140772 </br>3:Re: Pinto-Fraga et al.: Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: a randomized controlled clinical trial (Ophthalmology 2016;123:141-153). Estevez J, Pesudovs K.Ophthalmology. 2017 Feb;124(2):e14. doi: 10.1016/j.ophtha.2016.03.054. No abstract available. PMID: 28126079 </br>4:Comparison of the anti-inflammatory effects of fluorometholone 0.1% combined with levofloxacin 0.5% and tobramycin/dexamethasone eye drops after cataract surgery. Chen PQ, Han XM, Zhu YN, Xu J.Int J Ophthalmol. 2016 Nov 18;9(11):1619-1623. eCollection 2016. PMID: 27990365 Free PMC Article</br>5:Stability-Indicating RP-HPLC Methods for the Determination of Fluorometholone in Its Mixtures with Sodium Cromoglycate and Tetrahydrozoline Hydrochloride. El-Bagary RI, Fouad MA, El-Shal MA, Tolba EH.J Chromatogr Sci. 2016 Jul;54(6):923-33. doi: 10.1093/chromsci/bmw022. Epub 2016 Feb 26. PMID: 26921897 </br>6:Comparison of the Efficacy of Fluorometholone With and Without Benzalkonium Chloride in Ocular Surface Disease. Kim YH, Jung JC, Jung SY, Yu S, Lee KW, Park YJ.Cornea. 2016 Feb;35(2):234-42. doi: 10.1097/ICO.0000000000000695. PMID: 26619385 Free PMC Article</br>7:Topical Fluorometholone Protects the Ocular Surface of Dry Eye Patients from Desiccating Stress: A Randomized Controlled Clinical Trial. Pinto-Fraga J, López-Miguel A, González-García MJ, Fernández I, López-de-la-Rosa A, Enríquez-de-Salamanca A, Stern ME, Calonge M.Ophthalmology. 2016 Jan;123(1):141-53. doi: 10.1016/j.ophtha.2015.09.029. Epub 2015 Oct 29. PMID: 26520171 </br>8:Topical Fluorometholone Versus Diclofenac Sodium in Cases With Perennial Allergic Conjunctivitis. Li Z, Chen W, Zhang Y, Jhanji V, Fan Z, Mu G.Eye Contact Lens. 2015 Sep;41(5):310-3. doi: 10.1097/ICL.0000000000000127. PMID: 26322818 </br>9:Long-term Fluorometholone Topical Use Induces Ganglion Cell Damage in Rats Analyzed With Optical Coherence Tomography. Lin CH, Liao PL, Hsiao G, Li CH, Huang SH, Tsai CH, Wu MR, Lin FL, Ho JD, Cheng HW, Cheng YW.Toxicol Sci. 2015 Oct;147(2):317-25. doi: 10.1093/toxsci/kfv132. Epub 2015 Jul 2. PMID: 26141393 </br>10:Topical fluorometholone treatment for ocular dryness in patients with Sjögren syndrome: a randomized clinical trial in China. Lin T, Gong L.Medicine (Baltimore). 2015 Feb;94(7):e551. doi: 10.1097/MD.0000000000000551. PMID: 25700323 Free PMC Article |
