For research use only. Not for therapeutic Use.
Flupenthixol (Cat No.: I006819) is a thioxanthene-class antipsychotic used primarily for schizophrenia, depression, and other psychiatric disorders. It acts as a dopamine D1/D2 receptor antagonist, modulating neurotransmitter activity to reduce psychotic symptoms and improve mood stabilization. Flupenthixol exists in both low-dose (as an antidepressant) and high-dose (as an antipsychotic) formulations. Its long-acting depot formulation is beneficial for maintaining treatment adherence in chronic patients. Researchers study Flupenthixol for its effects on dopamine signaling, cognitive function, and mood disorders in neuropsychiatric research.
| CAS Number | 2709-56-0 |
| Synonyms | Flupenthixol, Flupenthixol, Depixol, Fluanxol, Emergil, Siplaril;2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol |
| Molecular Formula | C23H25F3N2OS |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol |
| InChI | 1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2 |
| InChIKey | NJMYODHXAKYRHW-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO |
| Reference | </br>1:Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia. Tardy M, Dold M, Engel RR, Leucht S.Cochrane Database Syst Rev. 2014 Sep 1;(9):CD009227. doi: 10.1002/14651858.CD009227.pub2. Review. PMID: 25177834 </br>2:Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders. Mahapatra J, Quraishi SN, David A, Sampson S, Adams CE.Cochrane Database Syst Rev. 2014 Jun 10;(6):CD001470. doi: 10.1002/14651858.CD001470.pub2. Review. PMID: 24915451 </br>3:Attenuation of acute d-amphetamine-induced disruption of conflict resolution by clozapine, but not α-flupenthixol in rats. Reichelt AC, Good MA, Killcross S.J Psychopharmacol. 2013 Nov;27(11):1023-31. doi: 10.1177/0269881113503503. Epub 2013 Sep 16. PMID: 24043725 </br>4:The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Wenzel JM, Su ZI, Shelton K, Dominguez HM, von Furstenberg VA, Ettenberg A.Pharmacol Biochem Behav. 2013 Dec;114-115:90-6. doi: 10.1016/j.pbb.2013.08.014. Epub 2013 Sep 5. PMID: 24012795 Free PMC Article</br>5:Flupenthixol versus placebo for schizophrenia. Shen X, Xia J, Adams CE.Cochrane Database Syst Rev. 2012 Nov 14;11:CD009777. doi: 10.1002/14651858.CD009777.pub2. Review. PMID: 23152280 </br>6:Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats. Chen YW, Chu CC, Chen YC, Leung YM, Wang JJ.Eur J Pharmacol. 2012 Oct 15;693(1-3):31-6. doi: 10.1016/j.ejphar.2012.07.039. Epub 2012 Aug 21. PMID: 22926199 </br>7:Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol. Jeyaseeli L, Dasgupta A, Dastidar SG, Molnar J, Amaral L.Eur J Clin Microbiol Infect Dis. 2012 Jun;31(6):1243-50. doi: 10.1007/s10096-011-1435-3. Epub 2011 Oct 14. PMID: 21997771 </br>8:Seeking-taking chain schedules of cocaine and sucrose self-administration: effects of reward size, reward omission, and α-flupenthixol. Veeneman MM, van Ast M, Broekhoven MH, Limpens JH, Vanderschuren LJ.Psychopharmacology (Berl). 2012 Apr;220(4):771-85. doi: 10.1007/s00213-011-2525-8. Epub 2011 Oct 12. PMID: 21989807 Free PMC Article</br>9:Flupenthixol-induced tardive dystonia presenting as severe dysphagia. Agarwal PA, Ichaporia NR.Neurol India. 2010 Sep-Oct;58(5):784-5. doi: 10.4103/0028-3886.72168. No abstract available. PMID: 21045513 Free Article</br>10:Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. Ismail N, Girard-Bériault F, Nakanishi S, Pfaus JG.Behav Neurosci. 2009 Oct;123(5):992-9. doi: 10.1037/a0017096. PMID: 19824765 |
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