For research use only. Not for therapeutic Use.
Flupentixol is a typical antipsychotic drug of the thioxanthene class. Flupentixol/’s main use is as a long-acting injection given once in every two or three weeks to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness. Flupentixol is also used in low doses as an antidepressant. There is tentative evidence that it reduces the rate of deliberate self-harm, among those who self harm repeatedly.
| Catalog Number | I006819 |
| CAS Number | 2709-56-0 |
| Synonyms | Flupenthixol, Flupenthixol, Depixol, Fluanxol, Emergil, Siplaril;2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol |
| Molecular Formula | C23H25F3N2OS |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| Reference | </br>1:Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia. Tardy M, Dold M, Engel RR, Leucht S.Cochrane Database Syst Rev. 2014 Sep 1;(9):CD009227. doi: 10.1002/14651858.CD009227.pub2. Review. PMID: 25177834 </br>2:Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders. Mahapatra J, Quraishi SN, David A, Sampson S, Adams CE.Cochrane Database Syst Rev. 2014 Jun 10;(6):CD001470. doi: 10.1002/14651858.CD001470.pub2. Review. PMID: 24915451 </br>3:Attenuation of acute d-amphetamine-induced disruption of conflict resolution by clozapine, but not α-flupenthixol in rats. Reichelt AC, Good MA, Killcross S.J Psychopharmacol. 2013 Nov;27(11):1023-31. doi: 10.1177/0269881113503503. Epub 2013 Sep 16. PMID: 24043725 </br>4:The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Wenzel JM, Su ZI, Shelton K, Dominguez HM, von Furstenberg VA, Ettenberg A.Pharmacol Biochem Behav. 2013 Dec;114-115:90-6. doi: 10.1016/j.pbb.2013.08.014. Epub 2013 Sep 5. PMID: 24012795 Free PMC Article</br>5:Flupenthixol versus placebo for schizophrenia. Shen X, Xia J, Adams CE.Cochrane Database Syst Rev. 2012 Nov 14;11:CD009777. doi: 10.1002/14651858.CD009777.pub2. Review. PMID: 23152280 </br>6:Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats. Chen YW, Chu CC, Chen YC, Leung YM, Wang JJ.Eur J Pharmacol. 2012 Oct 15;693(1-3):31-6. doi: 10.1016/j.ejphar.2012.07.039. Epub 2012 Aug 21. PMID: 22926199 </br>7:Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol. Jeyaseeli L, Dasgupta A, Dastidar SG, Molnar J, Amaral L.Eur J Clin Microbiol Infect Dis. 2012 Jun;31(6):1243-50. doi: 10.1007/s10096-011-1435-3. Epub 2011 Oct 14. PMID: 21997771 </br>8:Seeking-taking chain schedules of cocaine and sucrose self-administration: effects of reward size, reward omission, and α-flupenthixol. Veeneman MM, van Ast M, Broekhoven MH, Limpens JH, Vanderschuren LJ.Psychopharmacology (Berl). 2012 Apr;220(4):771-85. doi: 10.1007/s00213-011-2525-8. Epub 2011 Oct 12. PMID: 21989807 Free PMC Article</br>9:Flupenthixol-induced tardive dystonia presenting as severe dysphagia. Agarwal PA, Ichaporia NR.Neurol India. 2010 Sep-Oct;58(5):784-5. doi: 10.4103/0028-3886.72168. No abstract available. PMID: 21045513 Free Article</br>10:Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. Ismail N, Girard-Bériault F, Nakanishi S, Pfaus JG.Behav Neurosci. 2009 Oct;123(5):992-9. doi: 10.1037/a0017096. PMID: 19824765 |
