Fluphenazine decanoate dihydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I047595
  • CAS Number: 2376-65-0
  • Molecular Formula: C32H44F3N3O2S.2HCl
  • Molecular Weight: 664.69
  • Purity: ≥95%
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Fluphenazine (available after slow hydrolysis in vivo of the parent molecule) is a potent antipsychotic (Ki values 0.2 nM, 0.11 nM, and 2.0nM for D2, D3, and 5-HT2 receptors, respectively). Fluphenazine exhibits considerable affintiy for 5-HT6 and 5-HT7 receptors (Ki values 15.8nM and 7.9 nM, respectively) as well.


Catalog Number I047595
CAS Number 2376-65-0
Molecular Formula C32H44F3N3O2S.2HCl
Purity ≥95%
IUPAC Name 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate;dihydrochloride
InChI InChI=1S/C32H44F3N3O2S.2ClH/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35;;/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3;2*1H
SMILES CCCCCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl
Reference

H.L. Yale et al. Esters of 4-{3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl}-1-piperazineëthanol as long-acting tranquilizing agents. Synthesis of… J. Med. Chem., 1963, 6, 347-350.

 

P. Seeman et al. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol. Psychiatry. 1998, 3, 123-134.

 

B.L. Roth et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther. 1994, 268, 1403-1410.

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