For research use only. Not for therapeutic Use.
Fluridone is a herbicide, particularly to eliminate aquatic plant growth in water reservoirs and irrigation channels. Fluridone is a potent Abscisic acid (ABA) biosynthesis inhibitor, and has anti-inflammatory effects[1][2].
Fluridone (0.5-50 μM; for 4 days) inhibits the proliferation of aortic smooth muscle cells and reduces proliferation and cytokine release by human activated lymphocytes. In stimulated human monocytes, Fluridone inhibits COX-2 expression and the release of MCP-1 and prostaglandin-E2. Fluridone also inhibits the release from stimulated human monocytes of abscisic acid[1].
Fluridone (8.25 mg/kg; i.p.; once) reduces peritoneal inflammation in Zymosan-treated mice[1].
| Catalog Number | R019963 |
| CAS Number | 59756-60-4 |
| Synonyms | 1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]pyridin-4-one |
| Molecular Formula | C19H14F3NO |
| Purity | ≥95% |
| InChI | InChI=1S/C19H14F3NO/c1-23-11-16(13-6-3-2-4-7-13)18(24)17(12-23)14-8-5-9-15(10-14)19(20,21)22/h2-12H,1H3 |
| InChIKey | YWBVHLJPRPCRSD-UHFFFAOYSA-N |
| SMILES | CN1C=C(C(=O)C(=C1)C2=CC(=CC=C2)C(F)(F)F)C3=CC=CC=C3 |
| Reference | [1]. Mirko Magnone, et al. Fluridone as a new anti-inflammatory drug. Eur J Pharmacol. 2013 Nov 15;720(1-3):7-15. [2]. Wei X, et al. MYB41, MYB107, and MYC2 promote ABA-mediated primary fatty alcohol accumulation via activation of AchnFAR in wound suberization in kiwifruit. Hortic Res. 2020;7(1):86. |
