For research use only. Not for therapeutic Use.
Fluspirilene is a diphenylbutylpiperidine typical antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly.
| Catalog Number | R057781 |
| CAS Number | 1841-19-6 |
| Synonyms | 8-[4,4-Bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; Fluspirilen; Fluspiriline; Imap; McN-JR 6218; R 6218; Redeptin; |
| Molecular Formula | C29H31F2N3O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
| InChI | InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) |
| InChIKey | QOYHHIBFXOOADH-UHFFFAOYSA-N |
| SMILES | C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F |
| Reference | </br>1:In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug. Shi XN, Li H, Yao H, Liu X, Li L, Leung KS, Kung HF, Lu D, Wong MH, Lin MC.PLoS One. 2015 Jul 6;10(7):e0132072. doi: 10.1371/journal.pone.0132072. eCollection 2015. PMID: 26147897 Free PMC Article</br>2:Identification of antipsychotic drug fluspirilene as a potential p53-MDM2 inhibitor: a combined computational and experimental study. Patil SP, Pacitti MF, Gilroy KS, Ruggiero JC, Griffin JD, Butera JJ, Notarfrancesco JM, Tran S, Stoddart JW.J Comput Aided Mol Des. 2015 Feb;29(2):155-63. doi: 10.1007/s10822-014-9811-6. Epub 2014 Nov 7. PMID: 25377899 </br>3:Depot fluspirilene for schizophrenia. Abhijnhan A, Adams CE, David A, Ozbilen M.Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001718. Review. PMID: 17253464 </br>4:Inhibition of glutamate release by fluspirilene in cerebrocortical nerve terminals (synaptosomes). Wang SJ.Synapse. 2002 Apr;44(1):36-41. PMID: 11842444 </br>5:Depot fluspirilene for schizophrenia. Quraishi S, David A.Cochrane Database Syst Rev. 2000;(2):CD001718. Review. Update in: Cochrane Database Syst Rev. 2007;(1):CD001718. PMID: 10796446 </br>6:Determination of fluspirilene in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation. Swart KJ, Sutherland FC, van Essen GH, Hundt HK, Hundt AF.J Chromatogr A. 1998 Dec 18;828(1-2):219-27. PMID: 9916308 </br>7:[Fluspirilene–safe weekly tranquilizer?]. Kuhn W, Wöhrle M, Müller T, Welter F.Nervenarzt. 1997 Jun;68(6):528. German. No abstract available. PMID: 9312689 </br>8:Inhibition of synaptic transmission and epileptiform activity in central neurones by fluspirilene. Wang SJ, Lu KT, Gean PW.Br J Pharmacol. 1997 Mar;120(6):1114-8. PMID: 9134224 Free PMC Article</br>9:Test therapy in the treatment of generalized anxiety disorders with low dose fluspirilene. Wurthmann C, Klieser E, Lehmann E, Pester U.Prog Neuropsychopharmacol Biol Psychiatry. 1995 Oct;19(6):1049-60. PMID: 8584682 </br>10:[Interaction of therapeutic effects and side effects in drug therapy of generalized anxiety disorders with low dosage fluspirilene]. Wurthmann C, Klieser E, Lehmann E.Fortschr Neurol Psychiatr. 1995 Feb;63(2):72-7. German. PMID: 7705742 |
