Fluticasone Dimer Impurity

• CAT Number: R055946
• CAS Number: 220589-37-7
• Molecular Formula: C43H51F5O8S
• Molecular Weight: 822.92
• Purity: ≥95%
• Synonyms: (6α,11β,16α,17α)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-Androsta-1,4-diene-17-carboxylic Acid (6α,11β,16α,17α)-6,9-difluoro-17-[[(fluoromethyl)thio]carbonyl]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl Ester; Fluticasone Impurity G
• Target: Drug Metabolite
• Storage: Store at -20C
• IUPAC Name: [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylate
• InChI: InChI=1S/C43H51F5O8S/c1-20-11-24-26-15-30(45)28-13-22(49)7-9-36(28,3)40(26,47)32(51)17-38(24,5)42(20,55)34(53)56-43(35(54)57-19-44)21(2)12-25-27-16-31(46)29-14-23(50)8-10-37(29,4)41(27,48)33(52)18-39(25,43)6/h7-10,13-14,20-21,24-27,30-33,51-52,55H,11-12,15-19H2,1-6H3/t20-,21-,24+,25+,26+,27+,30+,31+,32+,33+,36+,37+,38+,39+,40+,41+,42+,43+/m1/s1
• InChIKey: GTZKCEBOBPLPHH-AMISWYLQSA-N
• SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)OC5(C(CC6C5(CC(C7(C6CC(C8=CC(=O)C=CC87C)F)F)O)C)C)C(=O)SCF)O)C)O)F)C)F

Fluticasone Dimer Impurity is a byproduct formed during the synthesis or degradation of fluticasone, a corticosteroid used in the treatment of asthma, allergies, and other inflammatory conditions. This impurity consists of two fluticasone molecules linked together, potentially altering its pharmacological activity. Monitoring and controlling the levels of Fluticasone Dimer Impurity is crucial for ensuring the safety, efficacy, and quality of the final pharmaceutical product. Its analysis is an important aspect of quality control in the production of fluticasone-based medications, contributing to regulatory compliance and patient safety.