Fluvastatin sodium

For research use only. Not for therapeutic Use.

  • CAT Number: I005581
  • CAS Number: 93957-55-2
  • Molecular Formula: C24H25FNO4 • Na
  • Molecular Weight: 433.50
  • Purity: ≥95%
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Fluvastatin sodium (Cat No.:I005581) is a medication belonging to the class of statins, which are commonly used to lower cholesterol levels in the body. Fluvastatin works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol synthesis. By reducing the production of cholesterol, fluvastatin helps to lower total cholesterol and low-density lipoprotein (LDL) cholesterol levels in the blood. It is primarily prescribed for the treatment of hypercholesterolemia and to reduce the risk of cardiovascular events in patients with a history of coronary artery disease.


Catalog Number I005581
CAS Number 93957-55-2
Synonyms

sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Molecular Formula C24H25FNO4 • Na
Purity ≥95%
Target HMG-CoA Reductase
Solubility 10 mM in DMSO
Storage 3 years -20C powder
IUPAC Name sodium;(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate
InChI InChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m1./s1
InChIKey ZGGHKIMDNBDHJB-NRFPMOEYSA-M
SMILES CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]
Reference

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[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [Epub ahead of print]&nbsp;
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[2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.&nbsp;
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[3]. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.&nbsp;
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[4]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.
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