For research use only. Not for therapeutic Use.
Fluxametamide (CAT: I019941) is an insecticide that exhibits a broad spectrum of activity against various pests. It functions as an antagonist of GABA (gamma-aminobutyric acid)-gated chloride channels and glutamate-gated chloride channels in insects. It has an IC50 value of 1.95 nM for GABACls (GABA-gated chloride channels) of Musca domestica (housefly) and an IC50 value of 225 nM for GluCls (glutamate-gated chloride channels). By blocking these chloride channels, fluxametamide disrupts inhibitory and excitatory neurotransmission in insects, leading to paralysis and ultimately causing insect death.
| Catalog Number | I019941 |
| CAS Number | 928783-29-3 |
| Molecular Formula | C₂₀H₁₆Cl₂F₃N₃O₃ |
| Purity | ≥95% |
| Reference | [1]. MihoAsahi, et al. Fluxametamide: A novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels. Pesticide Biochemistry and Physiology. |
