FMK 9a

• CAT Number: I013678
• CAS Number: 1955550-51-2
• Molecular Formula: C₂₃H₂₁FN₂O₃
• Molecular Weight: 392.42
• Purity: ≥95%
• Target: Autophagy
• Solubility: DMSO: ≥ 150 mg/mL
• Storage: under inert gas (nitrogen or Argon) at 2-8°C
• IUPAC Name: N-[(2S)-1-[(3-fluoro-2-oxopropyl)amino]-1-oxo-3-phenylpropan-2-yl]naphthalene-1-carboxamide
• InChI: InChI=1S/C23H21FN2O3/c24-14-18(27)15-25-23(29)21(13-16-7-2-1-3-8-16)26-22(28)20-12-6-10-17-9-4-5-11-19(17)20/h1-12,21H,13-15H2,(H,25,29)(H,26,28)/t21-/m0/s1
• InChIKey: VMVOHHPQIAPYHG-NRFANRHFSA-N
• SMILES: C1=CC=C(C=C1)CC(C(=O)NCC(=O)CF)NC(=O)C2=CC=CC3=CC=CC=C32

FMK 9a（Cat No.:I013678） is a small molecule inhibitor of autophagic-1, an enzyme involved in the regulation of autophagy. It inhibits autophagic-1 with IC50 values of 80 and 73 nM in fluorescence resonance energy transfer (FRET) and luciferase release assay (LRA), respectively. FMK 9a is cell-permeable and can penetrate the blood-brain barrier, making it a potential therapeutic agent for neurodegenerative disorders such as Alzheimer’s disease.

Reference

[1]. Qiu Z, et al. Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors. ACS Med Chem Lett. 2016 Jun 25;7(8):802-6.