FMOC-ARG(BOC)2-OH

• CAT Number: M104650
• CAS Number: 143824-77-5
• Molecular Formula: C31H40N4O8
• Molecular Weight: 596.67
• Purity: ≥95%
• Synonyms: (S)-5-[[Bis(Boc-amino)methylene]amino]-2-(Fmoc-amino)pentanoic Acid
• Storage: Store at -20C
• IUPAC Name: (2S)-5-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
• InChI: InChI=1S/C31H40N4O8/c1-30(2,3)42-28(39)34-26(35-29(40)43-31(4,5)6)32-17-11-16-24(25(36)37)33-27(38)41-18-23-21-14-9-7-12-19(21)20-13-8-10-15-22(20)23/h7-10,12-15,23-24H,11,16-18H2,1-6H3,(H,33,38)(H,36,37)(H2,32,34,35,39,40)/t24-/m0/s1
• InChIKey: WPAALELGEWGQEG-DEOSSOPVSA-N
• SMILES: CC(C)(C)OC(=O)NC(=NCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)NC(=O)OC(C)(C)C

FMOC-ARG(BOC)2-OH (CAS 143824-77-5) is an excellent derivative for Fmoc SPPS of Arg-containing peptides. Coupling of this derivative can be effected using standard activation methods, such as PyBOP® or TBTU, although longer reaction times may be necessary due to the bulkiness of the side-chain protection.

Reference

1.Cezari, M. H., and L. Juliano. "Studies on lactam formation during coupling procedures of N alpha-N omega-protected arginine derivatives." Peptide research 9.2 (1996): 88-91.