Fmoc-Gly-Gly-OH

• CAT Number: I015622
• CAS Number: 35665-38-4
• Molecular Formula: C₁₉H₁₈N₂O₅
• Molecular Weight: 354.36
• Purity: ≥95%
• Target: ADC Linker
• Storage: 2-8°C
• IUPAC Name: 2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid
• InChI: InChI=1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24)
• InChIKey: FBKUOPULLUJMOC-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCC(=O)NCC(=O)O

Fmoc-Gly-Gly-OH（Cat No.:I015622） is a cleavable ADC linker commonly utilized in the synthesis of antibody-drug conjugates (ADCs). It consists of an Fmoc-protected glycine-glycine dipeptide linked to a hydroxyl group. This linker is designed to provide stability during circulation in the body and facilitate controlled drug release at the target site. Upon internalization into target cells, the linker can be cleaved, allowing for the release of the attached drug moiety. Fmoc-Gly-Gly-OH offers versatility and compatibility with various drugs and antibodies, making it a valuable component in ADC development and drug delivery strategies.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.