Fmoc-His(Boc)-OH

• CAT Number: L042137
• CAS Number: 81379-52-4
• Molecular Formula: C26H27N3O6
• Molecular Weight: 477.51
• Purity: ≥95%
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[(2-methylpropan-2-yl)oxycarbonyl]imidazol-4-yl]propanoic acid
• InChI: InChI=1S/C26H27N3O6/c1-26(2,3)35-25(33)29-13-16(27-15-29)12-22(23(30)31)28-24(32)34-14-21-19-10-6-4-8-17(19)18-9-5-7-11-20(18)21/h4-11,13,15,21-22H,12,14H2,1-3H3,(H,28,32)(H,30,31)/t22-/m0/s1
• InChIKey: ZRHPMMZWDWMKPD-QFIPXVFZSA-N
• SMILES: CC(C)(C)OC(=O)N1C=C(N=C1)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-His(Boc)-OH(CAT: L042137) is a high-purity, protected histidine derivative widely used in peptide synthesis and pharmaceutical research. Featuring an Fmoc (9-fluorenylmethyloxycarbonyl) protecting group on the amino terminus and a Boc (tert-butoxycarbonyl) group on the imidazole side chain, this compound ensures stability and selective reactivity during solid-phase peptide synthesis (SPPS). Its dual protection simplifies complex peptide assembly, enabling efficient incorporation of histidine residues. Ideal for developing bioactive peptides, pharmaceuticals, and enzyme inhibitors, Fmoc-His(Boc)-OH offers consistent performance and high reliability in demanding synthetic protocols, making it a valuable tool in modern peptide chemistry.