Fmoc-HoCys(ACM)-OH

• CAT Number: M135805
• CAS Number: 150281-21-3
• Molecular Formula: C22H24N2O5S
• Molecular Weight: 428.50
• Purity: ≥95%
• Synonyms: (2S)-4-(acetamidomethylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
• InChI: InChI=1S/C22H24N2O5S/c1-14(25)23-13-30-11-10-20(21(26)27)24-22(28)29-12-19-17-8-4-2-6-15(17)16-7-3-5-9-18(16)19/h2-9,19-20H,10-13H2,1H3,(H,23,25)(H,24,28)(H,26,27)/t20-/m0/s1
• InChIKey: LKXJXPIRDOELQS-FQEVSTJZSA-N
• SMILES: CC(=O)NCSCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-HoCys(ACM)-OH, a homolog of cysteine, is synthesized from L-methionine. Fmoc-HoCys(ACM)-OH also can be used for the synthesis of solid phase peptide[1].
Fmoc-HoCys(ACM)-OH (compound 1) can be used in solid phase peptide synthesis using an Fmoc-based strategy[1].

Reference

[1]. Lutgring R, et, al. Synthesis of homologs of cysteine suitable for peptide and protein crosslinking. Bioorganic & Medicinal Chemistry Letters. 1993 Apr; 3(4): 739-742.