Fmoc-L-Leu-OH

• CAT Number: R020229
• CAS Number: 35661-60-0
• Molecular Formula: C21H23NO4
• Molecular Weight: 353.418
• Purity: ≥95%
• Synonyms: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine; (2S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-4-methylpentanoic Acid; (S)-N-Fmoc-leucine; 217: PN: US20070042401 PAGE: 29 claimed protein; 908: PN: WO2006135786 PAGE: 58 claimed protein; Fmoc-leuc
• Target: Vitamin D Related/Nuclear Receptor
• Storage: Room temperature
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
• InChI: InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
• InChIKey: CBPJQFCAFFNICX-IBGZPJMESA-N
• SMILES: CC(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Peroxisome proliferator-<wbr></wbr>activated receptor γ (PPARγ) isoforms heterodimerize with retinoic X receptors to modulate gene expression related to adipocyte differentiation, fatty acid uptake and storage, and glucose metabolis. Natural agonists of PPARγ include fatty acids (e.g., linoleic acid and 15-<wbr></wbr>deoxy-<wbr></wbr>Δ FMOC-<wbr></wbr>L-<wbr></wbr>leucine is a partial agonist of PPARγ. It activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone. FMOC-<wbr></wbr>L-<wbr></wbr>leucine improves insulin resistance in normal, diet-<wbr></wbr>induced glucose-<wbr></wbr>intolerant and in diabetic db/db mice, yet has reduced adipogenic activity. As a result, it is classified as a selective PPARγ modulator (SPPARM), capable of producing insulin-<wbr></wbr>sensitizing effects while minimizing side effects associated with full agonists.