Fmoc-N-Me-Phe-OH

• CAT Number: I019426
• CAS Number: 77128-73-5
• Molecular Formula: C₂₅H₂₃NO₄
• Molecular Weight: 401.46
• Purity: ≥95%
• Target: Parasite
• IUPAC Name: (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C25H23NO4/c1-26(23(24(27)28)15-17-9-3-2-4-10-17)25(29)30-16-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h2-14,22-23H,15-16H2,1H3,(H,27,28)/t23-/m0/s1
• InChIKey: GBROUWPNYVBLFO-QHCPKHFHSA-N
• SMILES: CN([C@@H](CC1=CC=CC=C1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-N-Me-Phe-OH（Cat No.:I019426）is a protected derivative of N-methyl-phenylalanine, widely used in peptide synthesis. The Fmoc (fluorenylmethyloxycarbonyl) group protects the amine group during solid-phase peptide synthesis, ensuring selective reactions and sequence fidelity. N-methylation enhances the compound’s structural stability, altering the peptide’s conformational properties and resistance to enzymatic degradation. Fmoc-N-Me-Phe-OH is valuable in designing bioactive peptides, including therapeutic agents and structural analogs for drug development. Its incorporation into peptides provides tools for studying protein-protein interactions, enhancing stability, and modulating biological activity in pharmaceutical and biochemical research.

Reference

[1]. Harris KS, et al. Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning. J Biol Chem. 2009 Apr 3;284(14):9361-71.