Fmoc-N-Me-Val-OH

• CAT Number: I019432
• CAS Number: 84000-11-3
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.41
• Purity: ≥95%
• Storage: 2-8°C
• IUPAC Name: (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methylbutanoic acid
• InChI: InChI=1S/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/m0/s1
• InChIKey: YCXXXPZNQXXRIG-IBGZPJMESA-N
• SMILES: CC(C)C(C(=O)O)N(C)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-N-Me-Val-OH is a modified peptide that contains the N-terminal Fmoc (9-fluorenylmethyloxycarbonyl) protecting group and a methyl (Me) substitution at the valine residue. The Fmoc group serves as a temporary protection for the amino group during peptide synthesis, allowing stepwise chain elongation. The N-Me-Val-OH modification introduces a methyl group at the valine residue, altering its properties. These modifications can impact the peptide’s stability, bioactivity, solubility, or other characteristics, making it useful for various research and synthetic applications in the field of peptide chemistry and drug development.

Reference

[1]. Harris KS, et al. Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning. J Biol Chem. 2009 Apr 3;284(14):9361-71.