Fmoc-NH-PEG1-C2-acid

• CAT Number: I016151
• CAS Number: 1654740-73-4
• Molecular Formula: C₂₀H₂₁NO₅
• Molecular Weight: 355.38
• Purity: ≥95%

Fmoc-NH-PEG1-C2-acid (CAT: I016151) is a PEG-based PROTAC linker specifically designed for use in the synthesis of PROTACs. This linker molecule combines a PEG moiety with a C2 spacer and a Fmoc-protected amine group, allowing for the efficient conjugation of various target-binding ligands or other functional groups to create PROTAC molecules. PROTACs are innovative compounds used to degrade specific target proteins by leveraging the cellular ubiquitin-proteasome system, and this linker plays a crucial role in connecting the key components of the PROTAC construct.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562