Fmoc-NH-PEG1-CH2COOH

• CAT Number: I016707
• CAS Number: 260367-12-2
• Molecular Formula: C₁₉H₁₉NO₅
• Molecular Weight: 341.36
• Purity: ≥95%
• Target: PROTAC

Fmoc-NH-PEG1-CH2COOH（Cat No.:I016707） is a cleavable linker widely employed in the synthesis of antibody-drug conjugates (ADCs). It acts as a connection between the antibody and the cytotoxic drug, facilitating targeted drug delivery. Furthermore, Fmoc-NH-PEG1-CH2COOH can serve as a PEG-based PROTAC linker in the construction of PROTACs (PROteolysis TArgeting Chimeras). In PROTACs, it serves as a flexible linker that connects the target protein binder and the E3 ligase recruiting moiety, enabling the selective degradation of the target protein. This versatile linker finds utility in the development of ADCs and PROTACs, contributing to targeted therapeutic strategies and protein manipulation in drug discovery and biomedical research.

Reference

[1]. Lorenzo Benatuil, et al. Anti-cd98 antibodies and antibody drug conjugates. WO2017214456A.