Fmoc-NH-PEG2-CH2CH2COOH

• CAT Number: I016716
• CAS Number: 872679-70-4
• Molecular Formula: C₂₂H₂₅NO₆
• Molecular Weight: 399.44
• Purity: ≥95%
• Target: PROTAC
• Storage: 2-8°C
• IUPAC Name: 3-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C22H25NO6/c24-21(25)9-11-27-13-14-28-12-10-23-22(26)29-15-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-8,20H,9-15H2,(H,23,26)(H,24,25)
• InChIKey: QWHLFJJLRVOHTM-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCC(=O)O

Fmoc-NH-PEG2-CH2CH2COOH（Cat No.:I016716） is a cleavable ADC linker employed in the construction of antibody-drug conjugates (ADCs). It acts as a bridge between the antibody and the drug payload, facilitating targeted delivery. Additionally, Fmoc-NH-PEG2-CH2CH2COOH can serve as a PEG-based PROTAC linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). By connecting the target protein binder and the E3 ligase recruiter, it promotes the degradation of specific proteins. This versatile linker plays a crucial role in the development of both ADCs and PROTACs, offering precise targeting and controlled drug release in therapeutic applications.

Reference

[1]. Fulcher JM, et al. Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag. Org Biomol Chem. 2019 Dec 28;17(48):10237-10244.