Fmoc-NH-PEG4-CH2COOH

• CAT Number: I017036
• CAS Number: 437655-95-3
• Molecular Formula: C₂₅H₃₁NO₈
• Molecular Weight: 473.52
• Purity: ≥95%
• Target: PROTAC
• Storage: 2-8°C
• IUPAC Name: 2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C25H31NO8/c27-24(28)18-33-16-15-32-14-13-31-12-11-30-10-9-26-25(29)34-17-23-21-7-3-1-5-19(21)20-6-2-4-8-22(20)23/h1-8,23H,9-18H2,(H,26,29)(H,27,28)
• InChIKey: XPNLDOFYRFOXLR-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCC(=O)O

Fmoc-NH-PEG4-CH2COOH（Cat No.:I017036） is a versatile linker molecule used in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (proteolysis-targeting chimeras). It consists of a PEG4 spacer with a Fmoc-protected amino group at one end and a carboxylic acid group at the other end. The Fmoc group can be selectively removed to expose the amino group for conjugation with a drug or target protein. The carboxylic acid group can be utilized for further functionalization or conjugation with other molecules, enabling the assembly of customized ADCs or PROTACs for targeted therapy.

Reference

[1]. Maggie Lu, et al. Linker-wirkstoff und antikörper-wirkstoff-konjugat (adc) damit. EP3335734A1.