Fmoc-NH-PEG5-CH2COOH

• CAT Number: I016908
• CAS Number: 635287-26-2
• Molecular Formula: C₂₇H₃₅NO₉
• Molecular Weight: 517.57
• Purity: ≥95%
• Target: PROTAC
• Storage: 2-8°C
• IUPAC Name: 2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C27H35NO9/c29-26(30)20-36-18-17-35-16-15-34-14-13-33-12-11-32-10-9-28-27(31)37-19-25-23-7-3-1-5-21(23)22-6-2-4-8-24(22)25/h1-8,25H,9-20H2,(H,28,31)(H,29,30)
• InChIKey: LNIFRTLAPAPKAG-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCC(=O)O

Fmoc-NH-PEG5-CH2COOH（Cat No.:I016908） is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (ADCs). It acts as a connector between the antibody and the cytotoxic drug, enabling targeted delivery. Additionally, Fmoc-NH-PEG5-CH2COOH can serve as a PEG-based PROTAC linker in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). As a PROTAC linker, it facilitates the connection between the target protein and the E3 ligase, leading to selective protein degradation.

Reference

[1]. Liuhong CHEN, et al. Multimeric bicyclic peptide ligands. WO2019162682A1.