Fmoc-NH-PEG6-CH2COOH

• CAT Number: I017015
• CAS Number: 437655-96-4
• Molecular Formula: C₂₉H₃₉NO₁₀
• Molecular Weight: 561.62
• Purity: ≥95%
• Target: PROTAC
• Storage: 2-8°C
• IUPAC Name: 2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C29H39NO10/c31-28(32)22-39-20-19-38-18-17-37-16-15-36-14-13-35-12-11-34-10-9-30-29(33)40-21-27-25-7-3-1-5-23(25)24-6-2-4-8-26(24)27/h1-8,27H,9-22H2,(H,30,33)(H,31,32)
• InChIKey: HANLHKUCDRJGKX-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCOCC(=O)O

Fmoc-NH-PEG6-CH2COOH（Cat No.:I017015） is a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs). It consists of a PEG (polyethylene glycol) chain, a linker containing a six-carbon spacer, and a carboxylic acid group. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a temporary protecting group that can be removed under specific conditions. This linker allows for the conjugation of drugs to antibodies and enables controlled release of the drug payload within target cells. Additionally, Fmoc-NH-PEG6-CH2COOH can also be used as a PEG-based PROTAC linker, facilitating the construction of PROTAC molecules for targeted protein degradation applications.

Reference

[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.