Fmoc-NH-PEG8-CH2COOH

• CAT Number: I016907
• CAS Number: 868594-52-9
• Molecular Formula: C₃₃H₄₇NO₁₂
• Molecular Weight: 649.73
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
• InChI: InChI=1S/C33H47NO12/c35-32(36)26-45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-10-9-34-33(37)46-25-31-29-7-3-1-5-27(29)28-6-2-4-8-30(28)31/h1-8,31H,9-26H2,(H,34,37)(H,35,36)
• InChIKey: JRLUSGRARXJCNA-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCC(=O)O

Fmoc-NH-PEG8-CH2COOH（Cat No.:I016907） is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a connection between the antibody and the cytotoxic payload, allowing for selective delivery of the drug to targeted cells. Additionally, Fmoc-NH-PEG8-CH2COOH can be utilized as a PEG-based PROTAC linker in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). In this context, it acts as a bridging component between the target protein and the E3 ligase, facilitating targeted protein degradation.

Reference

[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.