Fmoc-PEG1-CH2CH2-NHS ester

For research use only. Not for therapeutic Use.

  • CAT Number: I016389
  • CAS Number: 1807521-05-6
  • Molecular Formula: C24H24N2O7
  • Molecular Weight: 452.46
  • Purity: ≥95%
Inquiry Now

Fmoc-PEG1-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].


Catalog Number I016389
CAS Number 1807521-05-6
Synonyms

(2,5-dioxopyrrolidin-1-yl) 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]propanoate

Molecular Formula C24H24N2O7
Purity ≥95%
InChI InChI=1S/C24H24N2O7/c27-21-9-10-22(28)26(21)33-23(29)11-13-31-14-12-25-24(30)32-15-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-8,20H,9-15H2,(H,25,30)
InChIKey BGPXUJXGIVJFGP-UHFFFAOYSA-N
SMILES C1CC(=O)N(C1=O)OC(=O)CCOCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
 [Content Brief]

Request a Quote