Fmoc-PEG4-NHS ester

• CAT Number: I016425
• CAS Number: 1314378-14-7
• Molecular Formula: C₃₀H₃₆N₂O₁₀
• Molecular Weight: 584.61
• Purity: ≥95%
• Target: PROTAC Linkers

Fmoc-PEG4-NHS ester (CAT: I016425) stands as a PEG-based linker crucial for constructing PROTACs (PROteolysis Targeting Chimeras). With the capacity to synthesize PROTACs, it features two distinct ligands tethered by the linker—one binds to an E3 ubiquitin ligase, while the other engages the target protein. This unique molecular architecture capitalizes on the intracellular ubiquitin-proteasome system, enabling the selective degradation of specific target proteins. Fmoc-PEG4-NHS ester’s role lies in facilitating the assembly of these intricate PROTAC molecules, opening avenues for innovative drug development strategies with potential applications in targeted protein degradation therapies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.