Fmoc-PEG5-NHS ester

• CAT Number: I016424
• CAS Number: 1402080-11-8
• Molecular Formula: C₃₂H₄₀N₂O₁₁
• Molecular Weight: 628.67
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: 1S/C32H40N2O11/c35-29-9-10-30(36)34(29)45-31(37)11-13-39-15-17-41-19-21-43-22-20-42-18-16-40-14-12-33-32(38)44-23-28-26-7-3-1-5-24(26)25-6-2-4-8-27(25)28/h1-8,28H,9-23H2,(H,33,38)
• InChIKey: YYYFZVKBZSMQTP-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-PEG5-NHS ester (Cat No.: I016424) is a heterobifunctional crosslinker used in bioconjugation protocols. The compound features an NHS-activated ester, which reacts with primary amines, forming stable amide bonds, while the Fmoc group protects the N-terminus during peptide synthesis. The PEG5 spacer introduces hydrophilicity, reducing steric hindrance and improving solubility. Fmoc-PEG5-NHS ester is applied in protein labeling, peptide modifications, and drug delivery research, ensuring controlled conjugation. It improves polymeric scaffold design. Studies focus on optimizing reaction conditions and exploring new applications in biomedical science. ​

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.