Fmoc-Phe(3,5-DiF)-OH

• CAT Number: I043133
• CAS Number: 205526-24-5
• Molecular Formula: C24H19F2NO4
• Molecular Weight: 423.41
• Purity: ≥95%
• Synonyms: (2S)-3-(3,5-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
• InChI: InChI=1S/C24H19F2NO4/c25-15-9-14(10-16(26)12-15)11-22(23(28)29)27-24(30)31-13-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-10,12,21-22H,11,13H2,(H,27,30)(H,28,29)/t22-/m0/s1
• InChIKey: UYEQBZISDRNPFC-QFIPXVFZSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CC4=CC(=CC(=C4)F)F)C(=O)O

Fmoc-Phe(3,5-DiF)-OH（Cat No.:I043133）is a modified form of the amino acid phenylalanine, where the phenyl group is substituted with two fluorine atoms at the 3 and 5 positions (3,5-DiF). The amino group is protected with a 9-fluorenylmethyloxycarbonyl (Fmoc) group, enabling selective peptide synthesis. This derivative is used in solid-phase peptide synthesis (SPPS) to incorporate fluorine-modified phenylalanine into peptides, which can influence peptide structure and stability. Fmoc-Phe(3,5-DiF)-OH is useful in research involving protein folding, structural studies, and designing peptides with enhanced stability or specific binding properties for therapeutic applications.