Fmoc-Ser(tBu)-Thr(psi(Me,Me)pro)-OH

• CAT Number: I007187
• CAS Number: 1266350-99-5
• Molecular Formula: C₂₉H₃₆N₂O₇
• Molecular Weight: 524.61
• Purity: ≥95%

Fmoc-Ser(tBu)-Thr(psi(Me,Me)pro)-OH(CAT: I007187) is a specialized amino acid derivative often employed in peptide synthesis. It is constructed with the Fmoc (9-fluorenylmethoxycarbonyl) protecting group for amino termini and the tBu (tert-butyl) protecting group for the serine side chain hydroxyl group. Additionally, the psi(Me,Me)pro modification refers to the insertion of two methyl groups into the proline residue’s pyrrolidine ring, potentially altering peptide conformation and properties.

Reference

[1]. Emad Eid, et al. Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions. Bioconjug Chem. 2020 Mar 18;31(3):889-894.