Fmoc-Val-Ala-PAB-PNP

• CAT Number: I015255
• CAS Number: 1394238-92-6
• Molecular Formula: C₃₇H₃₆N₄O₉
• Molecular Weight: 680.7
• Purity: ≥95%
• Target: ADC Linker

Fmoc-Val-Ala-PAB-PNP(CAT: I015255) serves as a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). The realm of ADCs involves coupling an antibody with an ADC cytotoxin, and this linker plays a vital role in connecting these components. The linker’s cleavable nature is integral, allowing for controlled release of the cytotoxin within the targeted cells, enhancing the specificity and therapeutic impact of the ADC. Fmoc-Val-Ala-PAB-PNP contributes to the intricate design of ADCs, offering a versatile tool in the field of targeted cancer therapies and other precision medicine applications.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.