Fmoc-Val-Cit-PAB-PNP

• CAT Number: I005187
• CAS Number: 863971-53-3
• Molecular Formula: C40H42N6O10
• Molecular Weight: 766.8
• Purity: ≥95%
• Solubility: DMSO: ≥ 40 mg/mL
• Storage: 2-8°C(protect from light)
• IUPAC Name: [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C40H42N6O10/c1-24(2)35(45-39(50)54-23-33-31-10-5-3-8-29(31)30-9-4-6-11-32(30)33)37(48)44-34(12-7-21-42-38(41)49)36(47)43-26-15-13-25(14-16-26)22-55-40(51)56-28-19-17-27(18-20-28)46(52)53/h3-6,8-11,13-20,24,33-35H,7,12,21-23H2,1-2H3,(H,43,47)(H,44,48)(H,45,50)(H3,41,42,49)/t34-,35-/m0/s1
• InChIKey: USMYACISHVPTHK-PXLJZGITSA-N
• SMILES: CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

Fmoc-Val-Cit-PAB-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The linker consists of an N-terminal Fmoc group, a valine-citrulline dipeptide, a para-aminobenzyloxycarbonyl (PAB) spacer, and a p-nitrophenyl (PNP) leaving group. The PAB linker is cleaved by lysosomal enzymes, releasing the drug payload from the antibody.